Immunogenomics Laboratory
Antibody Diversification
To study the regulatory mechanism of lymphocyte receptor diversity including RAG-mediated V(D)J recombination and AID-mediated class switch recombination and somatic hypermutation
Antibody Evolution
To develop sequencing-based screening systems to identify monoclonal antibodies and design a cell-based system for antibody generation, maturation, and evolution
Genome Integrity
To study how the DNA response and repair system deals with DNA breaks in the context of chromatin control to maintain the genome integrity of lymphocytes
Genome Editing
Safety assessment of current genome editing toolboxes and development of new editing tools based on the mammalian immune system
Fork coupling directs DNA replication elongation and termination
Fork coupling directs DNA replication elongation and termination
Fork coupling directs DNA replication elongation and termination
Great Team
Our laboratory is well-established for self-motivated young scientists. We warmly welcome you to join us and build a positive, innovative, and active young team together. Our lab will make every effort to create opportunities for each participant to develop their talents and realize their aspirations.
Fork coupling directs DNA replication elongation and termination
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Dr. Yang Liu
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DR. Tingting Gan
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Yuefeng Guo
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Rusen Lu
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Yuhong Wang
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Lingyun Kong
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Xuhao Liu
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Zhengrong Zhangding
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Liqiong Ou
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Haoxin Liang
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Ziting Yang
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Xinyi Liu
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Dr. Yang Liu
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DR. Tingting Gan
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Yuefeng Guo
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Rusen Lu
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Yuhong Wang
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Lingyun Kong
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Xuhao Liu
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Zhengrong Zhangding
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Liqiong Ou
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Haoxin Liang
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Ziting Yang
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Xinyi Liu
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Wanlin Chen
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Wanqin Rao
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Jiayi Chen
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YOU
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Selected Publications
Fork coupling directs DNA replication elongation and termination
Yang Liu, Zhengrong Zhangding, Xuhao Liu, Tingting Gan, Chen Ai, Jinchun Wu, Haoxin Liang, Mohan Chen, Yuefeng Guo, Rusen Lu, Yongpeng Jiang, Xiong Ji, Ning Gao, Daochun Kong, Qing Li, Jiazhi HuScience 2024;383(6688):1215-1222. doi:10.1126/science.adj7606
PMID: 38484065
Cohesin maintains replication timing to suppress DNA damage on cancer genes
Wu J, Liu Y, Zhangding Z, Liu X, Ai C, Gan T, Liang H, Guo Y, Chen M, Liu Y, Yin J, Zhang W, Hu JNat Genet. 2023 Aug;55(8):1347-1358. doi: 10.1038/s41588-023-01458-z.
PMID: 37500731
Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration
Yin J, Fang K, Gao Y, Ou L, Yuan S, Xin C, Wu W, Wu WW, Hong J, Yang H, Hu J.Nat Commun. 2022 Dec 22;13(1):7867. doi: 10.1038/s41467-022-35640-4.
PMID: 36550137
Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies
Yin S, Zhang M, Liu Y, Sun X, Guan Y, Chen X, Yang L, Huo Y, Yang J, Zhang X, Han H, Zhang J, Xiao MM, Liu M, Hu J, Wang L, Li D.Mol Ther. 2022 Nov 30:S1525-0016(22)00672-4. doi: 10.1016/j.ymthe.2022.11.014.
PMID: 36457249
CRISPR/Cas9-induced structural variations expand in T lymphocytes in vivo.
Wu J, Zou Z, Liu Y, Liu X, Zhangding Z, Xu M, Hu J.Nucleic Acids Res. 2022 Oct 16:gkac887. doi: 10.1093/nar/gkac887.
PMID: 36243978
Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
Xin C, Yin J, Yuan S, Ou L, Liu M, Zhang W, Hu J.Nat Commun. 2022 Sep 24;13(1):5623. doi: 10.1038/s41467-022-33346-1.
PMID: 36153319
Long-term correction of haemophilia B through CRISPR/Cas9 induced homology-independent targeted integration
Chen X, Niu X, Liu Y, Zheng R, Yang L, Lu J, Yin S, Wei Y, Pan J, Sayed A, Ma X, Liu M, Jing F, Liu M, Hu J, Wang L, Li D.J Genet Genomics 2022 Jun 9:S1673-8527(22)00159-X. doi: 10.1016/j.jgg.2022.06.001
PMID: 35691554
The origin of unwanted editing byproducts in gene editing
Yin J, Hu J.Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(6):1-15. doi: 10.3724/abbs.2022056.
PMID: 35643959
C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency
Xie X, Gan T, Rao B, Zhang W, Panchakshari RA, Yang D, Ji X, Cao Y, Alt FW, Meng FL, Hu J.EMBO J. 2022 Jun 1;41(11):e109324. doi: 10.15252/embj.2021109324
PMID: 35471583
Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing.
Yin J, Lu R, Xin C, Wang Y, Ling X, Li D, Zhang W, Liu M, Xie W, Kong L, Si W, Wei P, Xiao B, Lee HY, Liu T, Hu J.Nat Commun. 2022 Mar 8;13(1):1204. doi: 10.1038/s41467-022-28900-w.
PMID: 35260581
PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair.
Liu Y, Yin J, Gan T, Liu M, Xin C, Zhang W, Hu J.STAR Protoc. 2022 Jan 17;3(1):101088. doi: 10.1016/j.xpro.2021.101088
PMID: 35462794