Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!

Welcome to Hulab!





Immunogenomics Laboratory


Antibody Diversification

To study the regulatory mechanism of lymphocyte receptor diversity including RAG-mediated V(D)J recombination and AID-mediated class switch recombination and somatic hypermutation

Antibody Evolution

To develop sequencing-based screening systems to identify monoclonal antibodies and design a cell-based system for antibody generation, maturation, and evolution

Genome Integrity

To study how the DNA response and repair system deals with DNA breaks in the context of chromatin control to maintain the genome integrity of lymphocytes

Genome Editing

Safety assessment of current genome editing toolboxes and development of new editing tools based on the mammalian immune system



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Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration


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Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration


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Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration




Great Team

    Our laboratory is well-established for self-motivated young scientists. We warmly welcome you to join us and build a positive, innovative, and active young team together. Our lab will make every effort to create opportunities for each participant to develop their talents and realize their aspirations.


doctor

Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration

read more

Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration

Education:

2006-2012      Ph.D        Peking University
2002-2006      B.S.          Peking University


Working Experiences:

2016-              PI           Peking University
2012-2016      Postdoc  Harvard Medical School


Awards:

2018        Qiu Shi Outstanding Youth Scholar
2016        Annual Distinguished Research Award in Life Science for Harvard Chinese
2014        Postdoctoral Fellowship at the American Cancer Research Center
2012        Ray Wu Prize



doctor

Dr. Yang Liu

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Dr. Yang Liu

Postdoc

Genome Integrity

Education/Working Experience:

2017-            Postdoc   Peking University

2011-2017    Ph.D        Peking University

2007-2011    B.S.          Beijing Normal University


doctor

DR. Tingting Gan

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DR. Tingting Gan

Ph.D student

Antibody Diversification

Education:

2022-            Postdoc    Peking University

2016-2021    Ph.D         Peking University

2012-2016    B.S.          Anhui University


doctor

Jianhang Yin

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Jianhang Yin

Ph.D student

Genome Editing

Education:

2016-            Ph.D student    Peking University
2011-2015    B.S.                  Peking University


doctor

Weiwei Zhang

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Weiwei Zhang

Ph.D student

Genome Editing

Education:

2016-            Ph.D student      Peking University
2009-2013    Bachelor            Xi'an Polytechnic University


doctor

Jinchun Wu

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Jinchun Wu

Ph.D student

Genome Integrity


Education:

2017-            Ph.D student    Peking University
2013-2017    B.S.                  Peking University


doctor

Changchang xin

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Changchang xin

Ph.D student

Genome Editing

Education:

2018-           Ph.D student    Peking University
2014-2018   B.S.                 Sun Yat-sen University


doctor

Yuefeng Guo

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Yuefeng Guo

Ph.D student

Antibody Diversification

Education:

2018-            Ph.D student    Peking University
2014-2018    B.S.                  Peking University


doctor

Rusen Lu

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Rusen Lu

Ph.D student

Antibody Diversification

Education:

2018-            Ph.D student    Peking University
2014-2018    B.S.                  Peking University


doctor

Yuhong Wang

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Yuhong Wang

Ph.D student

Antibody Diversification

Education:

2019-            Ph.D student    Peking University
2015-2019    B.S.                  University of Electronic and Science Technology of China


doctor

Lingyun Kong

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Lingyun Kong

Ph.D student

Antibody Diversification

Education:
2020-            Ph.D student      Peking University
2016-2020    B.S.                    Huazhong University of Science and Technology



doctor

Xuhao Liu

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Xuhao Liu



Education:
2021-            Ph.D student      Peking University
2017-2021    B.S.                    Peking University



doctor

Zhengrong Zhangding

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Zhengrong Zhangding



Genome Integrity

Education:
2021-            Ph.D student      Peking University
2017-2021    B.S.                    Huazhong Agriculture University



doctor

Liqiong Ou

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Liqiong Ou



Genome Editing

Education:
2021-            Ph.D student      Peking University
2017-2021    B.S.                    Sun Yat-sen University



doctor

Dr. Mengzhu Liu (Alumni)

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Dr. Mengzhu Liu (Alumni)

Ph.D student

Genome Editing

Education:

2015-2021    Ph.D    Peking University
2011-2015    B.S.     Lanzhou University


doctor

Dr. Chen Ai (Alumni)

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Dr. Chen Ai (Alumni)

Ph.D student

Genome Integrity

Education:

2016-2021    Ph.D        Peking University

2012-2016    B.S.          Huazhong University of Science and Technology


doctor

Dr. Zemin Tan (Alumni)

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Dr. Zemin Tan (Alumni)

Postdoc

Immunogenomics

Education:

2009-2015    Ph.D    China Agricultural University
2005-2009    B.S.     China Agricultural University


Working Experience:

2018-2020    PostDoc                 Peking University
2016-2018    R&D supervisor    Beijing kuxun biotechnology co. LTD
2015-2016    R&D supervisor    Beijing norhe zhiyuan biotechnology co. LTD

 

doctor

YOU

read more

YOU



We warmly welcome you to join us and build a positive, innovative, and active young team together.


doctor

Dr. Yang Liu

read more

Dr. Yang Liu

Postdoc

Genome Integrity

Education/Working Experience:

2017-            Postdoc   Peking University

2011-2017    Ph.D        Peking University

2007-2011    B.S.          Beijing Normal University


doctor

DR. Tingting Gan

read more

DR. Tingting Gan

Ph.D student

Antibody Diversification

Education:

2022-            Postdoc    Peking University

2016-2021    Ph.D         Peking University

2012-2016    B.S.          Anhui University


doctor

Jianhang Yin

read more

Jianhang Yin

Ph.D student

Genome Editing

Education:

2016-            Ph.D student    Peking University
2011-2015    B.S.                  Peking University


doctor

Weiwei Zhang

read more

Weiwei Zhang

Ph.D student

Genome Editing

Education:

2016-            Ph.D student      Peking University
2009-2013    Bachelor            Xi'an Polytechnic University


doctor

Jinchun Wu

read more

Jinchun Wu

Ph.D student

Genome Integrity


Education:

2017-            Ph.D student    Peking University
2013-2017    B.S.                  Peking University


doctor

Changchang xin

read more

Changchang xin

Ph.D student

Genome Editing

Education:

2018-           Ph.D student    Peking University
2014-2018   B.S.                 Sun Yat-sen University


doctor

Yuefeng Guo

read more

Yuefeng Guo

Ph.D student

Antibody Diversification

Education:

2018-            Ph.D student    Peking University
2014-2018    B.S.                  Peking University


doctor

Rusen Lu

read more

Rusen Lu

Ph.D student

Antibody Diversification

Education:

2018-            Ph.D student    Peking University
2014-2018    B.S.                  Peking University


doctor

Yuhong Wang

read more

Yuhong Wang

Ph.D student

Antibody Diversification

Education:

2019-            Ph.D student    Peking University
2015-2019    B.S.                  University of Electronic and Science Technology of China


doctor

Lingyun Kong

read more

Lingyun Kong

Ph.D student

Antibody Diversification

Education:
2020-            Ph.D student      Peking University
2016-2020    B.S.                    Huazhong University of Science and Technology



doctor

Xuhao Liu

read more

Xuhao Liu



Education:
2021-            Ph.D student      Peking University
2017-2021    B.S.                    Peking University



doctor

Zhengrong Zhangding

read more

Zhengrong Zhangding



Genome Integrity

Education:
2021-            Ph.D student      Peking University
2017-2021    B.S.                    Huazhong Agriculture University



doctor

Liqiong Ou

read more

Liqiong Ou



Genome Editing

Education:
2021-            Ph.D student      Peking University
2017-2021    B.S.                    Sun Yat-sen University



doctor

Dr. Mengzhu Liu (Alumni)

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Dr. Mengzhu Liu (Alumni)

Ph.D student

Genome Editing

Education:

2015-2021    Ph.D    Peking University
2011-2015    B.S.     Lanzhou University


doctor

Dr. Chen Ai (Alumni)

read more

Dr. Chen Ai (Alumni)

Ph.D student

Genome Integrity

Education:

2016-2021    Ph.D        Peking University

2012-2016    B.S.          Huazhong University of Science and Technology


doctor

Dr. Zemin Tan (Alumni)

read more

Dr. Zemin Tan (Alumni)

Postdoc

Immunogenomics

Education:

2009-2015    Ph.D    China Agricultural University
2005-2009    B.S.     China Agricultural University


Working Experience:

2018-2020    PostDoc                 Peking University
2016-2018    R&D supervisor    Beijing kuxun biotechnology co. LTD
2015-2016    R&D supervisor    Beijing norhe zhiyuan biotechnology co. LTD

 

doctor

YOU

read more

YOU



We warmly welcome you to join us and build a positive, innovative, and active young team together.


Selected Publications

Pubmed Link
Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration
Yin J, Fang K, Gao Y, Ou L, Yuan S, Xin C, Wu W, Wu WW, Hong J, Yang H, Hu J.
Nat Commun. 2022 Dec 22;13(1):7867. doi: 10.1038/s41467-022-35640-4.
PMID: 36550137
Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies
Yin S, Zhang M, Liu Y, Sun X, Guan Y, Chen X, Yang L, Huo Y, Yang J, Zhang X, Han H, Zhang J, Xiao MM, Liu M, Hu J, Wang L, Li D.
Mol Ther. 2022 Nov 30:S1525-0016(22)00672-4. doi: 10.1016/j.ymthe.2022.11.014.
PMID: 36457249
CRISPR/Cas9-induced structural variations expand in T lymphocytes in vivo.
Wu J, Zou Z, Liu Y, Liu X, Zhangding Z, Xu M, Hu J.
Nucleic Acids Res. 2022 Oct 16:gkac887. doi: 10.1093/nar/gkac887.
PMID: 36243978
Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
Xin C, Yin J, Yuan S, Ou L, Liu M, Zhang W, Hu J.
Nat Commun. 2022 Sep 24;13(1):5623. doi: 10.1038/s41467-022-33346-1.
PMID: 36153319
Long-term correction of haemophilia B through CRISPR/Cas9 induced homology-independent targeted integration
Chen X, Niu X, Liu Y, Zheng R, Yang L, Lu J, Yin S, Wei Y, Pan J, Sayed A, Ma X, Liu M, Jing F, Liu M, Hu J, Wang L, Li D.
J Genet Genomics 2022 Jun 9:S1673-8527(22)00159-X. doi: 10.1016/j.jgg.2022.06.001
PMID: 35691554
The origin of unwanted editing byproducts in gene editing
Yin J, Hu J.
Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(6):1-15. doi: 10.3724/abbs.2022056.
PMID: 35643959
C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency
Xie X, Gan T, Rao B, Zhang W, Panchakshari RA, Yang D, Ji X, Cao Y, Alt FW, Meng FL, Hu J.
EMBO J. 2022 Jun 1;41(11):e109324. doi: 10.15252/embj.2021109324
PMID: 35471583
Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing.
Yin J, Lu R, Xin C, Wang Y, Ling X, Li D, Zhang W, Liu M, Xie W, Kong L, Si W, Wei P, Xiao B, Lee HY, Liu T, Hu J.
Nat Commun. 2022 Mar 8;13(1):1204. doi: 10.1038/s41467-022-28900-w.
PMID: 35260581
PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair.
Liu Y, Yin J, Gan T, Liu M, Xin C, Zhang W, Hu J.
STAR Protoc. 2022 Jan 17;3(1):101088. doi: 10.1016/j.xpro.2021.101088
PMID: 35462794
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Keywords
antibody antigen B-cell crispr double-stranded breaks replication translocation