Immunogenomics Laboratory
Antibody Diversification
To study the regulatory mechanism of lymphocyte receptor diversity including RAG-mediated V(D)J recombination and AID-mediated class switch recombination and somatic hypermutation
Antibody Evolution
To develop sequencing-based screening systems to identify monoclonal antibodies and design a cell-based system for antibody generation, maturation, and evolution
Genome Integrity
To study how the DNA response and repair system deals with DNA breaks in the context of chromatin control to maintain the genome integrity of lymphocytes
Genome Editing
Safety assessment of current genome editing toolboxes and development of new editing tools based on the mammalian immune system
Transcription shapes DNA replication initiation to preserve genome integrity.
Transcription shapes DNA replication initiation to preserve genome integrity.
Transcription shapes DNA replication initiation to preserve genome integrity.
Great Team
Our laboratory is well-established for self-motivated young scientists. We warmly welcome you to join us and build a positive, innovative, and active young team together. Our lab will make every effort to create opportunities for each participant to develop their talents and realize their aspirations.
Transcription shapes DNA replication initiation to preserve genome integrity.
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DR. Tingting Gan
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Yuhong Wang
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Lingyun Kong
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Xuhao Liu
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Zhengrong Zhangding
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Liqiong Ou
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Haoxin Liang
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Ziting Yang
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Xinyi Liu
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Wanlin Chen
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Wanqin Rao
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Jiayi Chen
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YOU
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DR. Tingting Gan
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Yuhong Wang
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Lingyun Kong
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Xuhao Liu
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Zhengrong Zhangding
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Liqiong Ou
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Haoxin Liang
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Ziting Yang
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Xinyi Liu
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Wanlin Chen
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Selected Publications
Transcription shapes DNA replication initiation to preserve genome integrity.
Liu Y, Ai C, Gan T, Wu J, Jiang Y, Liu X, Lu R, Gao N, Li Q, Ji X, Hu J.Genome Biol. 2021 Jun 9;22(1):176. doi: 10.1186/s13059-021-02390-3.
PMID: 34108027
In-depth assessment of the PAM compatibility and editing activities of Cas9 variants.
Zhang W, Yin J, Zhang-Ding Z, Xin C, Liu M, Wang Y, Ai C, Hu J.Nucleic Acids Res. 2021 Sep 7;49(15):8785-8795. doi: 10.1093/nar/gkab507.
PMID: 34133740
Global detection of DNA repair outcomes induced by CRISPR-Cas9.
Liu M, Zhang W, Xin C, Yin J, Shang Y, Ai C, Li J, Meng FL, Hu J.Nucleic Acids Res. 2021 Sep 7;49(15):8732-8742. doi: 10.1093/nar/gkab686.
PMID: 34365511
RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination.
Gan T, Wang Y, Liu Y, Schatz DG, Hu J.Cell Rep. 2021 Oct 12;37(2):109824. doi: 10.1016/j.celrep.2021.109824.
PMID: 34644584