Investigating the mechanisms underlying DNA replication, DNA damage, and DNA recombination under complex chromatin environments and their impact on genome stability and tumorigenesis.
Immunogenomics Laboratory
Cells are the basic units of living organisms, each serving as a complex and intricate ecosystem, maintaining balance both internally and externally. Internally, cells possess complicated subcellular structures, with the nucleus serving as the container for genetic materials, characterized by a complex chromatin environment including hierarchic chromatin structures, multiple DNA metabolism activities, and epigenetic information. Externally, cell-cell communications are crucial for sustaining biological systems. While extensive research has been conducted on cell-cell communications with the immune and nervous systems, our current understanding is still limited. The immune system has a class of highly specific molecules - B cell receptors and T cell receptors, with the former secreted as antibodies. With rapid advancements in research technologies and the continuous accumulation of scientific data, the focus of research is gradually shifting from lower model organisms to humans themselves, with research becoming more systematic. In our laboratory, we primarily study immune cells from mice and humans, focusing on:
Antibody Diversification
Exploring changes in lymphocyte function and associated DNA metabolism changes over time and across different tissues, at temporal and spatial scales, during the aging process
Antibody Evolution
Studying the development and maturation mechanisms of antibodies and utilizing synthetic biology techniques to modify cells, promoting antibody production and antibody evolution
Genome Integrity
Investigating the mechanisms underlying DNA replication, DNA damage, and DNA recombination under complex chromatin environments and their impact on genome stability and tumorigenesis
DNA replication
Exploring the organization of DNA replication under complex chromatin environments in mammalian cells, especially the interplay between DNA replication and chromatin structures
Genomic Integrity
Antibody Diversification
Exploring changes in lymphocyte function and associated DNA metabolism changes over time and across different tissues, at temporal and spatial scales, during the aging process.
Great Team
Our laboratory is well-established for self-motivated young scientists. We warmly welcome you to join us and build a positive, innovative, and active young team together. Our lab will make every effort to create opportunities for each participant to develop their talents and realize their aspirations.
Dr. Jiazhi Hu
read more
DR. Tingting Gan
read more
Yuhong Wang
read more
Lingyun Kong
read more
Xuhao Liu
read more
Zhengrong Zhangding
read more
Liqiong Ou
read more
Haoxin Liang
read more
Ziting Yang
read more
Xinyi Liu
read more
Wanlin Chen
read more
Wanqin Rao
read more
Jiayi Chen
read more
YOU
read more
DR. Tingting Gan
read more
Yuhong Wang
read more
Lingyun Kong
read more
Xuhao Liu
read more
Zhengrong Zhangding
read more
Liqiong Ou
read more
Haoxin Liang
read more
Ziting Yang
read more
Xinyi Liu
read more
Wanlin Chen
read moreAlumni
Selected Publications
Chromosomal loop domains direct the recombination of antigen receptor genes.
Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW.Cell. Nov 5;163(4):947-59. doi: 10.1016/j.cell.2015.10.016.
PMID: 26593423
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.
Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW.Nat Biotechnol. 2015 Feb;33(2):179-86. doi: 10.1038/nbt.3101.
PMID: 25503383